Recombinant Human EGF Protein (GMP Grade) 

GMP级重组人表皮生长因子蛋白

目录号规格单价
PM117-0110 μg160
PM117-0250 μg400
PM117-031 mg1120
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产品详情介绍

表皮生长因子(Epidermal Growth Factor, EGF)是一种具有促进细胞增殖和分化作用的多肽,由53个氨基酸组成,并通过三个内部二硫键形成特定的空间结构[1]。EGF与其受体(Epidermal Growth Factor Receptor, EGFR)结合后,能够激活受体内的酪氨酸激酶活性,这一过程对于细胞内信号传导至关重要[2]。EGF在多种生物学过程中发挥作用,包括细胞的增殖、分化、迁移和凋亡[3]。重组人表皮生长因子(rhEGF)的外源性给药已知可促进皮肤伤口愈合,并在药物输送系统和纳米技术中越来越广泛地使用[4]

产品组成

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References

[1] Lu, H., Chai, J., Li, M., Huang, B., He, C., & Bi, R. Crystal Structure of Human Epidermal Growth Factor and Its Dimerization. The Journal of Biological Chemistry. 2001, 276, 34913 - 34917.

[2] Schneider, M., & Wolf, E. The epidermal growth factor receptor ligands at a glance. Journal of Cellular Physiology. 2009, 218.

[3] Bazley, L.,  Gullick, W. The epidermal growth factor receptor family. Endocrine-related cancer, 2005, 12 Suppl 1, S17-27.

[4] Shin, S., Koh, Y., Lee, W., Seok, J., & Park, K.. The use of epidermal growth factor in dermatological practice. International Wound Journal. 2022, 20, 2414 - 2423.


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