产品详情介绍
纤维连接蛋白（Fibronectin，FN），又称纤粘蛋白，能促进细胞的黏连生长，而细胞的黏连是机体结构得以维持、细胞生长完成的必要条件。因此，FN是细胞培养基的重要成分之一。此外FN能提高细胞的融合率，缩短融合周期[1-3]。血浆纤维连接蛋白由肝细胞分泌，并结合到细胞表面，转变为延伸构象并组装成纤维连接蛋白纤维[4]。另外，由于FN的EDA和EDB结构域在肿瘤血管中特异性表达，它们被广泛用于靶向递送细胞因子、细胞毒素、化疗药物和放射性同位素，以对原发癌和转移病变产生治疗效果[5]。
[1] Kelsh-Lasher RM, Ambesi A, Bertram C, McKeown-Longo PJ. Integrin α4β1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain. J Invest Dermatol. 2017, 137(12):2505-2512.
[2] Amin A, Chikan NA, et al. Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells. Sci Rep. 2016, 6:37151.
[3] Dhanesha N, Ahmad A, Prakash P, Doddapattar P, Lentz SR, Chauhan AK. Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation. Circulation. 2015, 132(23):2237-2247.
[4] Maurer LM, Ma W, Mosher DF. Dynamic structure of plasma fibronectin. Crit Rev Biochem Mol Biol. 2015, 51(4):213-227.
[5] Kumra H, Reinhardt DP. Fibronectin-targeted drug delivery in cancer. Adv Drug Deliv Rev. 2016, 97:101-110.
