产品详情介绍
玻连蛋白（Vitronectin，VTN），是一种多功能的糖蛋白，存在于血浆和细胞外基质中。玻连蛋白通过Arg-Gly-Asp (RGD) 序列介导，特定的细胞表面受体如整联蛋白αVβ3和αVβ5结合，从而参与多种生理过程，在细胞的粘附、迁移、增殖和分化等过程中发挥重要作用[1-3]。它还可以与多种配体结合，如糖胺聚糖、胶原蛋白、纤溶酶原和尿激酶受体，并稳定纤溶酶原激活抑制剂-1 的抑制构象[4]。玻连蛋白可促进内皮细胞贴附，伸展和增殖，促进多种正常细胞及癌细胞的分化，可用于细胞迁移实验的研究[5]。VTN参与凝血、抑制膜攻击复合物 (MAC) 的形成、细胞粘附和迁移、伤口愈合和组织重塑[6]。
[1] Suzuki S, Pierschbacher MD, Hayman EG, Nguyen K, Ohgren Y, Ruoslahti E. Domain structure of vitronectin. Alignment of active sites. J Biol Chem. 1984, 259(24):15307-15314.
[2] Hayman EG, Pierschbacher MD, Ohgren Y, Ruoslahti E. Serum spreading factor (vitronectin) is present at the cell surface and in tissues. Proc Natl Acad Sci USA. 1983, 80(13):4003-4007.
[3] Brown PJ, Juliano RL. Selective inhibition of fibronectin-mediated cell adhesion by monoclonal antibodies to a cell-surface glycoprotein. Science. 1985, 228(4706):1448-1451.
[4] Pytela R, Pierschbacher MD, Ruoslahti E. A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin. Proc Natl Acad Sci USA. 1985, 82(17):5766-5770.
[5] Zou B, Yuan Q, et al. Combination of Fushengong decoction with Western medicine on patients with chronic renal failure: An observational study. Medicine (Baltimore). 2024, 103(15): e37473.
[6] Wijler LA, Viergever BJ, et al. Onward Spread from Liver Metastases Is a Major Cause of Multi-Organ Metastasis in a Mouse Model of Metastatic Colon Cancer. Cancers (Basel). 2024, 16(5):1073.
