产品详情介绍
干细胞因子（Stem cell factor, SCF），也称为KIT配体，是一种结合酪氨酸激酶受体（c-kit）的细胞因子。SCF也被称为“c-kit配体”[1-2]。SCF是一种对造血干细胞和其他造血祖细胞的存活、增殖和分化很重要的生长因子。其作用之一是将红细胞系列中最早的红细胞前体BFU-E（突发形成单位红细胞）细胞转变为CFU-E（集落形成单位红细胞）[3]。重组SCF可以与G-CSF联合使用，提高外周血中CD34+细胞的浓度，动员外周血祖细胞（PBPC），快速恢复癌症患者的骨髓造血功能。在自体造血干细胞移植中，SCF的使用可以增加动员到外周血的造血干细胞数量，有助于收集足够数量的干细胞以进行移植[4]。
[1] Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, Murdock DC, et al. Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor[J]. Cell, 1990, 63(1):213-224.
[2] Williams DE, Lyman SD. Characterization of the gene-product of the Steel locus. Prog Growth Factor Res, 1991,3(4):235-242.
[3] Bazan JF. Genetic and structural homology of stem cell factor and macrophage colony-stimulating factor. Cell, 1991, 65(1):9-10.
[4] da Silva, M., Pimentel, P., Carvalhais, A. et al. Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection. Bone Marrow Transplant, 2004, 34, 683–691.
