产品详情介绍
HLA-DR是由36 kDa α链和27 kDa β链组成的异二聚体，由6号染色体短臂的MHC基因复合物编码。两条链可由许多不同的等位变异形态出现，存在高度的多态性。HLA-DR结构性表达在抗原递呈细胞上，主要表达于免疫系统的细胞[1]。HLA-DR在单核细胞上强表达，尤其是CD14＋CD16＋亚群[2]；在巨噬细胞、粒细胞、浆样树突状细胞、小胶质细胞、郎格汉斯细胞上亦可表达[1,3,4]。HLA-DR还可表达于一些造血细胞的幼稚阶段，例如BFU-E，但不表达在CFU-E或原红细胞[5]。本产品为小鼠抗人HLA-DR单克隆抗体，用于IF和FC方法特异性检测人HLA-DR蛋白。
CD系列产品介绍视频
[1] Ting JP, TROWSDALE J. Genetic control of MHC class II expression [J]. Cell. 2002, 109 Suppl: S21-33.
[2] Passlick B, Flieger D, Ziegler-Heitbrock HW. Identification and characterization of a novel monocyte subpopulation in human peripheral blood [J]. Blood. 1989, 74(7): 2527-34.
[3] Mattiace LA, Davies P, Dickson DW. Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors [J]. Am J Pathol. 1990, 136(5): 1101-14.
[4] Angel CE, George E, Ostrovsky LL, et al. Comprehensive analysis of MHC-II expression in healthy human skin [J]. Immunol Cell Biol. 2007, 85(5): 363-9.
[5] Nakahata T, Okumura N. Cell surface antigen expression in human erythroid progenitors:erythroid and megakaryocytic markers [J]. Leuk Lymphoma. 1994, 13(5-6): 401-9.
