产品详情介绍
CD166又称为活化白细胞细胞粘附分子（ALCAM），是免疫球蛋白超家族的成员，在胞外区有五个免疫球蛋白样结构域（VVC2C2C2）[1]。它在脐血造血干细胞、淋巴管内皮细胞、皮肤、扁桃体、外周血单核细胞、单核细胞衍生的树突状细胞上均有表达[2-5]。另外，CD166通过与T细胞表面糖蛋白CD6的相互作用促进T细胞的活化与增殖[4,5]。本产品为小鼠抗人CD166单克隆抗体，用于FC方法特异性检测人CD166蛋白。
CD系列产品介绍视频
[1] Bowen MA, Patel DD, Li X, et al. Cloning, Mapping, and Characterization of Activated Leukocyte-Cell Adhesion Molecule (ALCAM), a CD6 Ligand [J]. J Exp Med. 1995, 181: 2213-20.
[2] Chitteti B R, Kobayashi M, Cheng Y, et al. CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche [J]. Blood. 2014, 124(4): 519-29.
[3] Iolyeva M, Karaman S, Willrodt AH, et al. Novel role for ALCAM in lymphatic network formation and function [J]. FASEB J. 2013, 27(3): 978-90.
[4] Hassan NJ, Barclay AN, Brown MH. Frontline: Optimal T cell activation requires the engagement of CD6 and CD166 [J]. Eur J Immunol. 2004, 34(4): 930-40.
[5] Zimmerman AW, Joosten B, Torensma R, et al. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells [J]. Blood. 2006, 107(8): 3212-20.
